Nasus is a top-lane fighter. He really struggles in the early game but once you reach the late game and have a lot of stacks from Siphoning Strike, you have the potential to one-shot enemies. The way you get stacks from Siphoning Strike is by using the ability to last hit minions. This is the most important thing with Nasus and you must do this to help yourself win the game. Once you reach the late game you can 1 vs 1 a lot of champions and take down towers really quickly.
Nasus uses a mixture of both damage and tank items that work well with her kit. Divine Sunderer is a great first item for Nasus. This item gives him both damage and tank stats. Divine Sunderer's passive effect, Spellblade, also work great with Nasus' abilities, especially Siphoning Strike. Hullbreaker is a very strong item for Nasus when you are ahead and if you are looking to split push for the rest of the game. If you want to group with your team I would recommend skipping this item and building Spirit Visage instead.
For runes, we have the following:
As Nasus you will always be in the face of your enemy as you are mainly a melee champion and you will be tanking a lot of damage. So when you auto-attack champions, you will gain some extra health from this rune.
With Nasus you will be in a lot of team fights trying to kill the enemy carries so dealing extra damage will always help and Nasus restores health every time she gets a takedown.
Nullifying Orb is a great rune that gives Nasus a shield that absorbs incoming damage when he drops low on health. This will help you survive that little bit longer so you can escape to safety or go in for the killing blow.
Demolish works well with champions that love to split push and build Hullbreaker like Nasus. Demolish helps you push and destroy towers very quickly which can give you and your team a huge advantage.
Nasus struggles a lot in the early game. You need to make sure you play passive in the early game unless you have a great opportunity to go in if the enemies makes a mistake. In the laning phase, you want to stack your Siphoning Strike as much as possible on every minion. If you get poked early on, you have an inbuilt physical vamp with Soul Eater that can help you heal up. Nasus can also poke back a bit with Spirit Fire.
Once you get to the late game and you have your core items plus plenty of stacks with Siphoning Strike, you can start to fight and become unstoppable. At this stage of the game, the best thing you can do is split-push, this means going to one of the side lanes (top or bottom) and pushing the minions. Nasus' 1 vs 1 potential is really good because of his kit and he pushes towers really fast. When it comes to a 5 vs 5 team fight, your main goal is to get on top of the enemy backline! Use your Wither on the enemy carry to reduce their attack speed and movement speed and use Fury of The Sands to stay alive.
Overall Nasus is a very easy champion to play. If you are ok with farming in the early game and want to run down in the late game and be able to one-shot any champion then Nasus is the best champion for you.
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