Kai'Sa Build Guide for Wild Rift

Second Skin (Passive)

Kai'Sa has two parts to her passive Second Skin.
The first part is Living Weapon, which allows Kai'sa to evolve her basic abilities every time she completes a tier 3 item. The most important evolution to go for is Icathain Rain, which gives Kai'sa insane early and scaling damage.

The second passive is Caustic Wounds. Kai'Sa's attacks, her 2nd ability Void Seeker and her allies' immobilizing effects stack Plasma on the enemy. This makes any support with crowd control great with Kai'Sa, as the support can help you stack the passive. The number of stacks on the target can be seen just below the champion/minion. Once you get four stacks on an enemy, the 5th attack deals bonus magic damage equal to a percentage of their missing health.

Icathian Rain (1)

Launches six missiles that split evenly among nearby enemies, each dealing physical damage. When Kai'Sa isolates an enemy, all the missiles go onto that enemy and do a lot of burst damage. Icathian Rain is also an excellent tool during the laning phase. This ability can poke down enemy champions and hit minions simultaneously. Make sure the enemy champions and minions are in range of your ability, and the missiles will spread to all targets.

Living Weapon: Instead of launching six missiles, you will launch 12. That's double the number of missiles and you guessed it, double the amount of damage! When completing your first tier 3 item, you can get this upgrade at around 4/5 minutes, which will be a huge power spike of damage you can deal.

Void Seeker (2)

Kai'sa fires a blast that reveals the first enemy hit, adds two Plasma (Passive) stacks, and deals magic damage. There are two ways you can use this ability to its full potential.

The first is to increase the speed at which you get your stacks for your passive. Hitting enemies with Void Seeker adds two stacks. Using this ability between your attacks is a great way to get to 5 stacks as quickly as possible to deal more damage quickly.

The second is to use Void Seeker to mark enemies from far away so you can use your Ultimate (Killer Instinct) on the target to surprise them. This is mainly useful in the mid/late game; if you can catch someone out by themselves, you can quickly get a kill and an advantage for your team.

Living Weapon: Now your Void Seeker will add three stacks of your passive and lower the cooldown when it hits an enemy champion. When playing AD Kai'sa, you don't want to focus too much on this upgrade, however if you're playing AP Kai'sa, you want to get this evolved 2nd.

Supercharge (3)

When activated, the ability charges up, gaining movement speed. After the charge is finished, Kai'Sa gains attack speed. This adds mobility to Kai'Sa's kit and gives her more attack speed. However, when you are charging, you cannot attack, you can only use Icathian Rain. In the early game, the best time to use this ability is at the start when you know you are about to go into a teamfight.

Living Weapon: When you activate Supercharge, you will become invisible during the charge-up. This makes this ability strong in the mid/late game. Use the ability to throw off your enemies and move to a different location when you are invisible, surprising them with your vast amount of damage.

Killer Instinct (Ultimate)

Allows Kai'Sa to dash to a location near an enemy champion marked by Plasma (Passive), gaining a shield that absorbs damage for a few seconds. This is your primary ability to outplay the enemy and get an advantage for your team.

When you are in a duel at close range, you can use Killer Instinct to avoid enemy damage, skill shots and crowd control or use it to gain a shield when duelling vs an enemy champion. This allows you to reposition and get a shield to help you survive.

Another way you can use Killer Instinct is to jump onto the enemy backline to assassinate them. Be careful when doing this; if you get caught, you will die very quickly.